Buy Simvastatin Online (Zocor) 20mg 28 Tablets

Buy Simvastatin Online (Zocor) 20mg 28 Tablets
Buy Simvastatin Online (Zocor) 20mg 28 Tablets
Product Code: Simvastatin
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This is how simvastatin is used
The use of simvastatin is usually as a tablet once a day in the evening. The individual dose is determined by the doctor, but is usually between five and eighty milligrams.

Regular use is important for the success of the treatment, as the blood cholesterol levels usually change over a period of weeks. Patients do not "notice" the effect of the cholesterol-lowering drug directly, although it is measurable in the blood. The unauthorized discontinuation of cholesterol-lowering drugs, if no "effect" is noticed, is strongly discouraged.

Often, simvastatin is combined with other drugs, such as the anion exchanger colestyramine - also a cholesterol-lowering agent. It prevents the bile acids released in the intestine from being absorbed back into the blood to aid digestion. As a result, the liver is forced to form new bile acids from cholesterol - the cholesterol level drops.

What side effects does simvastatin have?
Side effects rarely occur with simvastatin therapy (in one in every one thousand to ten thousand patients). These include:

Anemia, dizziness, headache
Muscle weakness, pain, cramping (especially with high doses of simvastatin)
Muscle pain and symptoms with simvastatin therapy are serious side effects and should be clarified immediately with the attending physician.

What should be considered when taking Simvastatin?
The treatment of children and adolescents (10 to 17 years) takes place only in special cases and is subject to certain restrictions to be clarified by the doctor. Use in children under the age of ten has not been studied.

Pregnant and breastfeeding women should not take simvastatin. If breast-feeding is absolutely necessary, it should be stopped before the start of simvastatin therapy.

Because simvastatin is broken down by, among others, the enzyme cytochrome 3A4, inhibitors of this enzyme lead to increased levels and thus increased simvastatin side effects. The following drugs should therefore not be combined with simvastatin:

Certain remedies for fungal infections (antifungals): ketoconazole, itraconazole, fluconazole
Other medications that should not be combined because of a potential increase in simvastatin side effects are:

Ciclosporin (in autoimmune diseases and after organ transplants)
Heart medications and calcium channel blockers (amiodarone, verapamil, diltiazem, amlodipine)
In addition, the use of grapefruit juice should be avoided during simvastatin therapy. Only one glass of grapefruit juice in the morning will cause twice as many simvastatin levels to be measured the next night - the possible consequences are unexpected side effects.

How to get medicines with simvastatin
Simvastatin is available only in pharmacies by prescription.

Since when is Simvastatin known?
After elucidating the biosynthesis of cholesterol in the early 1950s, it quickly became apparent that by inhibiting important key enzymes, one could produce effective medicines for elevated cholesterol levels. Specifically against the enzyme HMG-CoA reductase, a first inhibitor called mevastatin was isolated from a fungus in Japan in 1976. However, this was never brought to market. In 1979, scientists from Merck & Co. (now MSD Sharp & Dohme) isolated lovastatin from a fungus. Synthetically modified variants of lovastatin were also developed during the study, with compound MK-733 (later simvastatin) proving to be therapeutically more effective than the starting material. Both substances were then approved by Merck & Co..

Buy Simvastatin Online (Zocor) 10 or 20mg 28 Tablets

The active ingredient simvastatin is one of the statins. Simvastatin is an important drug to treat high cholesterol levels. It is generally considered to be well tolerated; a rare simvastatin side effect is muscle pain. Here you can read everything important about Simvastatin, side effects and application.

How does simvastatin work?
The body needs cholesterol to transport fats in the blood, among other things. About two-thirds of the required amount of cholesterol is produced by the body in the liver itself, and one third is derived from the diet. If the cholesterol level is too high, one can reduce its own production, but it often helps to fundamentally change the diet.

The production of cholesterol in the liver is a complex process, but effectively arises from activated acetic acid, a substance often found in cells, through many steps cholesterol during the. An important and rate-limiting step in this cholesterol biosynthesis depends on a particular enzyme called HMG-CoA reductase. Statins such as simvastatin inhibit this step - this reduces the production of our own blood and lowers the cholesterol levels of the blood (especially the "bad" LDL cholesterol, and the "good" HDL cholesterol sometimes even increases).

Simvastatin is taken up quickly after oral intake and converted to active form by the liver. The maximum simvastatin effect occurs about one to two hours after ingestion. Since the body is the most intense cholesterol during the night, simvastatin is usually taken in the evening.

The metabolized simvastatin is excreted mainly via the stool, only a small part is released via the urine.

When will Simvastatin be used?
Simvastatin is mainly used in high cholesterol levels (hypercholesterolemia) in the blood. Before starting therapy, it is always important to try to normalize non-drug cholesterol levels, such as healthy diet, exercise and weight loss.

Simvastatin is also approved for the prevention of cardiovascular complications in patients with coronary heart disease (CHD) or an increased risk of cardiovascular disease (such as diabetes patients) - regardless of the level of cholesterol levels.

The application is usually long-term in both cases.

 

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