Novomix 30 Penfill Buy Online Insulin Aspart 3 ml 5 Penfills

Novomix 30 Penfill Buy Online Insulin Aspart 3 ml 5 Penfills
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Novomix 30 Penfill Buy Online Insulin Aspart 3 ml 5 Penfill

NovoMix® 30 is a modern insulin (insulin analogue) with both a rapid-acting and an intermediate- acting effect, in the ratio 30/70. Modern insulin products are improved versions of human insulin.

NovoMix® 30 is used to reduce the high blood sugar level in adults, adolescents and children aged 10 years and above with diabetes mellitus (diabetes). Diabetes is a disease where your body does not produce enough insulin to control the level of your blood sugar. NovoMix® 30 may be used in combination with tablets for diabetes.

NovoMix® 30 will start to lower your blood sugar 10–20 minutes after you inject it, the maximum effect occurs between 1 and 4 hours after the injection, and the effect lasts for up to 24 hours.

2. What you need to know before you use NovoMix® 30

Do not use NovoMix® 30

  • ►  If you are allergic to insulin aspart or any of the other ingredients in this medicine (see section 6, Contents of the pack and other information).

  • ►  If you suspect hypoglycaemia (low blood sugar) is starting, see a) Summary of serious and very common side effects in section 4.

  • ►  In insulin infusion pumps.

  • ►  If the cartridge or the device containing the cartridge is dropped, damaged or crushed.

  • ►  If it has not been stored correctly or if it has been frozen, see section 5, How to store NovoMix®

    30.

  • ►  If the resuspended insulin does not appear uniformly white, cloudy and aqueous.

  • ►  If after resuspension, clumps of material are present or if solid white particles stick to the

    bottom or the wall of the cartridge.

If any of these apply, do not use NovoMix® 30. Talk to your doctor, nurse or pharmacist for advice.

Before using NovoMix® 30

  • ►  Check the label to make sure it is the right type of insulin.

  • ►  Always check the cartridge, including the rubber plunger at the bottom of the cartridge. Do not

    use it if any damage is seen or if the rubber plunger has been drawn above the white label band at the bottom of the cartridge. This could be the result of an insulin leakage. If you suspect that the cartridge is damaged, take it back to your supplier. See your pen manual for further instructions.

  • ►  Always use a new needle for each injection to prevent contamination.

  • ►  Needles and NovoMix® 30 Penfill® must not be shared.

    Warnings and precautions

    Some conditions and activities can affect your need for insulin. Consult your doctor:

    • ►  If you have trouble with your kidneys or liver, or with your adrenal, pituitary or thyroid glands.

    • ►  If you exercise more than usual or if you want to change your usual diet, as this may affect your

      blood sugar level.

    • ►  If you are ill, carry on taking your insulin and consult your doctor.

    • ►  If you are going abroad, travelling over time zones may affect your insulin needs and the timing

      hereof.

      Children and adolescents

      • NovoMix® 30 can be used in adolescents and children aged 10 years and above.

      • There is limited experience with NovoMix® 30 in children aged 6–9 years.

      • No data are available for NovoMix® 30 in children below 6 years of age.

        Other medicines and NovoMix® 30

        Tell your doctor, nurse or pharmacist if you are taking, have recently taken or might take any other medicines. Some medicines affect your blood sugar level and this may mean that your insulin dose has to change. Listed below are the most common medicines which may affect your insulin treatment.

        Your blood sugar level may fall (hypoglycaemia) if you take:

      • Other medicines for the treatment of diabetes

      • Monoamine oxidase inhibitors (MAOI) (used to treat depression)

      • Beta-blockers (used to treat high blood pressure)

      • Angiotensin converting enzyme (ACE) inhibitors (used to treat certain heart conditions or high

        blood pressure)

      • Salicylates (used to relieve pain and lower fever)

      • Anabolic steroids (such as testosterone)

      • Sulfonamides (used to treat infections).

        Your blood sugar level may rise (hyperglycaemia) if you take:

      • Oral contraceptives (birth control pills)

      • Thiazides (used to treat high blood pressure or excessive fluid retention)

      • Glucocorticoids (such as ‘cortisone’ used to treat inflammation)

      • Thyroid hormones (used to treat thyroid gland disorders)

      • Sympathomimetics (such as epinephrine [adrenaline], salbutamol or terbutaline used to treat

        asthma)

      • Growth hormone (medicine for stimulation of skeletal and somatic growth and pronounced

        influence on the body’s metabolic processes)

• Danazol (medicine acting on ovulation).

Octreotide and lanreotide (used for treatment of acromegaly, a rare hormonal disorder that usually occurs in middle-aged adults, caused by the pituitary gland producing excess growth hormone) may either increase or decrease your blood sugar level.

Beta-blockers (used to treat high blood pressure) may weaken or suppress entirely the first warning symptoms which help you to recognise low blood sugar.

Pioglitazone (tablets used for the treatment of type 2 diabetes)
Some patients with long-standing type 2 diabetes and heart disease or previous stroke who were treated with pioglitazone and insulin experienced the development of heart failure. Inform your doctor as soon as possible if you experience signs of heart failure such as unusual shortness of breath or rapid increase in weight or localised swelling (oedema).

If you have taken any of the medicines listed here, tell your doctor, nurse or pharmacist.

Drinking alcohol and taking NovoMix® 30

If you drink alcohol, your need for insulin may change as your blood sugar level may either rise or fall. Careful monitoring is recommended.

Pregnancy and breast-feeding

  • ►  If you are pregnant, think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking this medicine. There is limited clinical experience with insulin aspart in pregnancy. Your insulin dose may need to be changed during pregnancy and after delivery. Careful control of your diabetes, particularly prevention of hypoglycaemia, is important for the health of your baby.

  • ►  There are no restrictions on treatment with NovoMix® 30 during breast-feeding.

    Ask your doctor, nurse or pharmacist for advice before taking any medicine while pregnant or breast- feeding.

    Driving and using machines

Please ask your doctor whether you can drive a car or operate a machine:

  • If you have frequent hypoglycaemia.

  • If you find it hard to recognise hypoglycaemia.

    If your blood sugar is low or high, it might affect your concentration and ability to react and therefore also your ability to drive or operate a machine. Bear in mind that you could endanger yourself or others.

    Important information about some of the ingredients in NovoMix® 30

    NovoMix® 30 contains less than 1 mmol sodium (23 mg) per dose, i.e. NovoMix® 30 is essentially ‘sodium-free’.

3. How to use NovoMix® 30

Dose and when to take your insulin

Always use your insulin and adjust your dose exactly as your doctor has told you. Check with your

doctor, nurse or pharmacist if you are not sure.
NovoMix® 30 is generally taken immediately before a meal. Eat a meal or snack within 10 minutes of the injection to avoid low blood sugar. When necessary, NovoMix® 30 can be given soon after a meal. See
How and where to inject, below for information.

When NovoMix® 30 is used in combination with tablets for diabetes, the dose should be adjusted.

Do not change your insulin unless your doctor tells you to. If your doctor has switched you from one type or brand of insulin to another, your dose may have to be adjusted by your doctor.

Use in children and adolescents

NovoMix® 30 can be used in adolescents and children aged 10 years and above when premixed insulin is preferred. Limited clinical data exists for children aged 6–9 years. No data are available for NovoMix® 30 in children below 6 years of age.

Use in special patient groups

If you have reduced kidney or liver function, or if you are above 65 years of age, you need to check your blood sugar more regularly and discuss changes in your insulin dose with your doctor.

How and where to inject

NovoMix® 30 is for injection under the skin (subcutaneously). Never inject your insulin directly into a vein (intravenously) or muscle (intramuscularly).
With each injection, change the injection site within the particular area of skin that you use. This may reduce the risk of developing lumps or skin pitting (see section 4,
Possible side effects). The best places to give yourself an injection are: the front of your waist (abdomen); your buttocks; the front of your thighs or upper arms. The insulin will work more quickly if you inject around the waist. You should always measure your blood sugar regularly.

  • ►  Do not refill the cartridge.

  • ►  NovoMix® 30 Penfill® cartridges are designed to be used with Novo Nordisk insulin delivery

    systems and NovoFine® or NovoTwist® needles.

  • ►  If you are treated with NovoMix® 30 Penfill® and another insulin Penfill® cartridge, you

    should use two insulin delivery systems, one for each type of insulin.

  • ►  Always carry a spare Penfill® cartridge in case the one in use is lost or damaged.

    Resuspension of NovoMix® 30

    Always check if there is enough insulin left (at least 12 units) in the cartridge to allow even resuspension. If there is not enough insulin left, use a new one. See your pen manual for further instructions.

Every time you use a new NovoMix® 30 Penfill® (before you put the cartridge into the insulin delivery system)

  • Let the insulin reach room temperature before you use it. This makes it easier to resuspend.

  • Roll the cartridge between your palms 10 times – it is important that the cartridge is kept

    horizontal (level with the ground) (see picture A).

  • Move the cartridge up and down between positions a and b (see picture B) 10 times so that the

    glass ball moves from one end of the cartridge to the other.

  • Repeat the rolling and moving procedures (see pictures A and B) until the liquid does appear

    uniformly white, cloudy and aqueous. Do not use the cartridge if the resuspended insulin does

    not look uniformly white, cloudy and aqueous.

  • Complete the other stages of injection without delay.

For every following injection

Move the delivery system with the cartridge inside up and down between a and b (see picture B) at least 10 times until the liquid appears uniformly white, cloudy and aqueous. Do not use the cartridge if the resuspended insulin does not look uniformly white, cloudy and aqueous. Complete the other stages of injection without delay.

How to inject NovoMix® 30

  • ►  Inject the insulin under your skin. Use the injection technique advised by your doctor or nurse and as described in your pen manual.

  • ►  Keep the needle under your skin for at least 6 seconds. Keep the push-button fully depressed until the needle has been withdrawn from the skin. This will ensure correct delivery and limit possible flow of blood into the needle or insulin reservoir.

  • ►  After each injection, be sure to remove and discard the needle and store NovoMix® 30 without the needle attached. Otherwise the liquid may leak out, which can cause inaccurate dosing.

    If you take more insulin than you should

    If you take too much insulin, your blood sugar gets too low (hypoglycaemia). See a) Summary of serious and very common side effects in section 4.

    If you forget to take your insulin

    If you forget to take your insulin, your blood sugar may get too high (hyperglycaemia). See c) Effects from diabetes in section 4.

    If you stop taking your insulin

    Do not stop taking your insulin without speaking with a doctor, who will tell you what needs to be done. This could lead to very high blood sugar (severe hyperglycaemia) and ketoacidosis. See c) Effects from diabetes in section 4.

    If you have any further questions on the use of this medicine, ask your doctor, nurse or pharmacist.

4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

a) Summary of serious and very common side effects

Low blood sugar (hypoglycaemia) is a very common side effect. It may affect more than 1 in 10 people.

Low blood sugar may occur if you:

  • Inject too much insulin.

  • Eat too little or miss a meal.

  • Exercise more than usual.

  • Drink alcohol (see Drinking alcohol and taking NovoMix® 30 in section 2).

    Signs of low blood sugar: Cold sweat; cool pale skin; headache; rapid heartbeat; feeling sick; feeling very hungry; temporary changes in vision; drowsiness; unusual tiredness and weakness; nervousness or tremor; feeling anxious; feeling confused; difficulty in concentrating.

    Severe low blood sugar can lead to unconsciousness. If prolonged severe low blood sugar is not treated, it can cause brain damage (temporary or permanent) and even death. You may recover more quickly from unconsciousness with an injection of the hormone glucagon given by someone who knows how to use it. If you are given glucagon, you will need glucose or a sugar snack as soon as you are conscious. If you do not respond to glucagon treatment, you will have to be treated in a hospital.

    What to do if you experience low blood sugar:

  • ►  If you experience low blood sugar, eat glucose tablets or another high sugar snack (e.g. sweets, biscuits, fruit juice). Measure your blood sugar if possible and rest. Always carry glucose tablets or high sugar snacks with you, just in case.

  • ►  When the symptoms of low blood sugar have disappeared or when your blood sugar level is stabilised, continue insulin treatment as usual.

  • ►  If you have such low blood sugar that it makes you pass out, if you have had the need for an injection of glucagon, or if you have experienced many incidents of low blood sugar, talk to a doctor. The amount or timing of insulin, food or exercise may need to be adjusted.

    Tell relevant people that you have diabetes and what the consequences may be, including the risk of passing out (becoming unconscious) due to low blood sugar. Let them know that if you pass out, they must turn you on your side and get medical help straight away. They must not give you any food or drink because you may choke.

    Serious allergic reactions to NovoMix® 30 or one of its ingredients (called a systemic allergic reaction) is a very rare side effect, but it can potentially be life-threatening. It may affect less than 1 in 10,000 people.

    Seek medical advice immediately:

  • If signs of allergy spread to other parts of your body.

  • If you suddenly feel unwell, and you: start sweating; start being sick (vomiting); have difficulty

    in breathing; have a rapid heartbeat; feel dizzy.

If you notice any of these signs, seek medical advice immediately.

b) List of other side effects

Uncommon side effects

May affect less than 1 in 100 people.

Signs of allergy: Local allergic reactions (pain, redness, hives, inflammation, bruising, swelling and itching) at the injection site may occur. These usually disappear after a few weeks of taking your insulin. If they do not disappear, see your doctor.

Vision problems: When you first start your insulin treatment, it may disturb your vision, but the disturbance is usually temporary.

Changes at the injection site (lipodystrophy): The fatty tissue under the skin at the injection site may shrink (lipoatrophy) or thicken (lipohypertrophy). Changing the site with each injection reduces the risk of developing such skin changes. If you notice your skin pitting or thickening at the injection site, tell your doctor or nurse. These reactions can become more severe, or they may change the absorption of your insulin, if you inject in such a site.

Swollen joints: When you start taking insulin, water retention may cause swelling around your ankles and other joints. Normally, this soon disappears. If not, contact your doctor.

Diabetic retinopathy (an eye disease related to diabetes which can lead to loss of vision): If you have diabetic retinopathy and your blood sugar level improves very fast, the retinopathy may get worse. Ask your doctor about this.

Rare side effects

May affect less than 1 in 1,000 people.

Painful neuropathy (pain due to nerve damage): If your blood sugar level improves very fast, you may get nerve related pain. This is called acute painful neuropathy and is usually transient.

Reporting of side effects

If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via 

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