Buy Ketosteril Online (Methionine) Essential Amino Acid 600 mg 100 Tablets

 Buy Ketosteril Online (Methionine) Essential Amino Acid 600 mg 100 Tablets
 Buy Ketosteril Online (Methionine) Essential Amino Acid 600 mg 100 Tablets
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 Buy Ketosteril Online (Methionine) Essential Amino Acid 600 mg 100 Tablets 

Ketosteril is a medicine which is used to treat  High Creatinine in urine or blood. The generic name of Ketosteril is methionine, is a type of Essential Amino Acids helping to lower the high creatinine level in body.  Ketosteril is produced (manufactured) by  Fresenius Kabi. Each pack of Ketosteril contains 100 tablets (600 mg essential amino acid for each tablet)

  Ketosteril generally known as Compound α-Ketoacid Tablets and it is used for preventing and treating renal damages due to protein metabolism disorder in chronic kidney disease (CKD)  and the effects are better with low-protein diets. It is usually applied to those that have glomerular filtration rate (GFR) less than 25ml/min and the standard of low-protein diet is 40g/day or less for adults.

There are many treatments for Chronic Kidney Failure and in recent years both eastern and western scholars advocate the use of ketosteril to treat chronic kidney disease and help lower creatinine level. Metabolic disorders of protein, amino acid are very common among renal failure patients and they are in a state of negative nitrogen balance. Ketosteril can supply amino acid and reduce the producing of urea and help lower the level of creatinine and urea nitrogen and at the same time improve the nutritional status.

Ketosteril is generally known as compound α-Ketoacid Tablets and it has certain effects on reducing high creatinine level. Along with low-protein diets, it can be used to prevent and treat protein metabolic disorder due to renal dysfunction. It usually will be prescribed for kidney patients that have GFR lower than 25ml/min. Low protein diet is 40g/d or less per day for adults.

Ketosteril can supply amino acids and at the same time reduce urea production as well as protein-related metabolic wastes and toxins so as to lower high creatinine and BUN, alleviate uremic state and improve nutritional state. It can help increase protein synthesis, reduce protein decomposition and prevent protein leakage from the kidney so as to increase plasma albumin.

Besides lowering high creatinine and reducing protein loss in urine, ketosteril can help rectify metabolic acidosis, improve metabolic disorders of calcium, phosphorus, fat, sugar and protein as well as preserving residual renal functional units.

However, lowering creatinine level should not be the final goal because it is only the symptom reflecting renal damages. Only if the root problem is solved can further relapse of high creatinine be prevented. In this regard, patients should not only rely on ketosteril because it can not repaired damaged renal tissues and recover kidney functions though it can help lower creatinine and slow down the illness progression.

Increase of creatinine, BUN and other wastes is due to decline of glomerular excretion ability and impairment of renal functions. Only if renal damages are repaired and kidney functions are improved can excessive creatinine be discharged with urine thought the kidneys and creatinine will be reduced naturally. What is more important, patients need not to worry about the on and off of high creatinine because the root problem has been solved.

If ketosteril is combined with Micro-Chinese medicine, the effects will be better. Micro-Chinese medicine has the functions of anti-inflammation, anti-coagulation, degradation of extracellular matrix and promoting blood circulation so as to block renal fibrosis, repair damaged renal intrinsic cells and tissues and restore renal structure and part of renal functions. This can help lower high creatinine naturally and effectively from the long run.

The combination of ketosteril and low-protein diet can achieve the following functions:

1. Alleviate the symptoms of uremia. The symptoms and discomforts of uremia are caused by the excessive accumulation of metabolic wastes of proteins.

2. Protect the remaining renal functions and slow down the progression of illness conditions.

3. Guarantee the patients’ nutrition even with obvious reduction of protein intake.

4. Improve the metabolic complications due to renal insufficiency.

While ketosteril has so many effects in treating kidney disease, it still has many side effects.

 Ketosteril  Side Effects 

Ketosteril, along with low-protein diets, has been used in clinic to help lower creatinine and treat chronic renal failure, especially those that have GFR lower than 25ml/min.

With low-protein diets (less than 40g/d for adults), ketosteril can be taken for long-term use. It can make use of nitrogens of non-essential amino acids and turn into essential amino acids so as to reduce urea production and at the same time avoiding malnutrition due to lack of protein intake.

Toxicologic study has shown that ketosteril has very low toxicity and it has no feta toxicity. Chronic toxicology research has shown that the minimum poisoning dose for dog is 1200mg/d and for rats it is 2700mg/d.

However ketosteril does cause some side effects at the same time of reducing high creatinine level. It can cause hypercalcemia (high blood calcium) and metabolic disorder of amino acids. High blood calcium can increase cardiac glycoside drugs and increase the risk of cardiac arrhythmia.

In case of hypercalcemia, patients should reduce intake of vitamin D. If hypercalcemia lasts, reduce dosage of ketosteril and the intake of calcium-containing substances.

Besides, hereditary phenylketonuria patients should pay more attention while taking ketosteril because it contains phenylalanine.

Until now, there is no experience of using the ketosteril on gravida and lactation women.

Some notes that helps lower and prevent side effects of ketosteril:

1. Take ketosteril between meals so that the active ingredients can be fulled absorbed and turned into according amino acids.

2. Have regular and close monitoring of blood calcium level and have adequate calorie intake.

3. Reduce the dosage of aluminium hydroxide drugs of you are taking ketosteril and aluminium hydroxide at the same time.

4. Monitor serum phosphorus level.

5. Have at least 2 hours interval between taking ketosteril and the following medicines including tetracydine, quinolones like cipro, norfloxacin, iron, fluoride, etc.

Ketosteril drug classification

Manufacturer of Ketosteril Fresenius Kabi
 Distributor of Ketosteril  Fresenius Kabi
  Ketosteril Contents Amino acids.
Ketosteril Indications Prevention and therapy of damages due to faulty or deficient protein metabolism in chronic renal insufficiency in connection with limited protein in food of ≤40 g/day (for adults) ie, generally in patients with a glomerular filtration rate (GFR) <25 mL/min.
Ketosteril Dosage & Administration For oral use. Swallow whole.
Adults (70 kg body weight): If not otherwise prescribed take 4-8 tablets 3 times a day during meals.
Ketosteril is given as long as the GFR is <25 mL/min and a diet with an intake of maximum 40 g protein/day (for adults) is followed.
Ketosteril Overdosage No symptoms have been observed to date.
 Ketosteril Contraindications Hypercalcaemia, disturbed amino acid metabolism.
In case of hereditary phenylketonuria, it has to be taken into account that Ketosteril contains phenylalanine.
Ketosteril Special Precautions Ketosteril should be taken during meals to allow proper absorption and metabolism into the corresponding amino acids. The serum calcium level should be monitored regularly.
Ensure the sufficient supply with calories.
Effects on the Ability to Drive or Operate Machinery: Not applicable.
Use in pregnancy & lactation: No experience has been made so far with the application in pregnancy and lactation.
Use in children: No experience has been made so far with the application in paediatric.
Ketosteril Adverse Drug Reactions Hypercalcaemia may develop. In this case, it is recommended to decrease vitamin D intake.
If the hypercalcaemia persists, reduce the dosage of Ketosteril as well as any other source of calcium. 
Ketosteril Drug Interactions The simultaneous administration of medicaments containing calcium (eg, acetolyte) may lead to pathological increases of the serum calcium level or intensification.
As the uraemic symptoms improve under Ketosteril, a possible administration of aluminium hydroxide should be reduced. Pay attention to a reduction of serum phosphate.
In order not to interfere with absorption, do not take drugs together with Ketosteril that form sparingly soluble compounds with calcium (eg, tetracyclines, quinolone eg, ciprofloxacin and norfloxacin, iron-, fluoride- and estramustin-containing drugs). Between the intake of Ketosteril and drugs from the mentioned categories, a period of at least 2 hrs should pass.
The susceptibility towards heart/cardiac-active glycosides and hence also the risk of arrhythmia increases with the raise of the blood calcium concentration.
Incompatibilities: None.
Ketosteril Storage Do not store above 25°C.
Shelf-Life: 3 years.
Ketosteril Description Each tablet contains (RS)-3-methyl-2-oxovaleric acid (α-ketoanalogue to DL-isoleucine), calcium-salt 67 mg; 4-methyl-2-oxovaleric acid (α-ketoanalogue to leucine), calcium-salt 101 mg; 2-oxo-3-phenylpropionic acid (α-ketoanalogue to phenylalanine), calcium-salt 68 mg; 3-methyl-2-oxobutyric acid (α-ketoanalogue to valine), calcium salt 86 mg; (RS)-2-hydroxy-4-methylthio-butyric acid (α-hydroxyanalogue to DL-methionine), calcium salt 59 mg; L-lysine acetate 105 mg; L-threonine 53 mg; L-tryptophan 23 mg; L-histidine 38 mg; L-tyrosine 30 mg. 
Total nitrogen content per tablet: 36 mg. Calcium content per tablet: 1.25 mmol = 50 mg.
Ketosteril also contains the following excipients: Cornstarch, crospovidone, talc, silicone dioxide, magnesium stearate, macrogol 6000, quinoline yellow E104, poly[butylmethacrylate-co-(2-dimethylaminoethyl)metha-crylate-co-methylmetha-crylate] 1:2:1 (Eudragit E), triactine, titanium dioxide E171, povidone K-value 29-32.
Ketosteril Mechanism of Action Pharmacology: Pharmacodynamics: Ketosteril allows the intake of essential amino acids while minimising the amino-nitrogen intake.
Following ingestion, the ketoanalogues are transaminated by taking nitrogen from non-essential amino acids, thereby decreasing the formation of urea by re-using the amino group. The levels of accumulating uremic toxins are decreased. Keto- and/or hydroxy-acids do not elicit hyperfiltration of residual nephrons. Ketoacid-containing supplements have a positive influence on the renal hyperphosphatemia and secondary hyperparathyroidism and can improve renal osteodystrophy. The use of Ketosteril in association with a very low protein diet allows a reduced intake of nitrogen while avoiding the deleterious consequences of inadequate dietary protein intake and malnourishment.
Pharmacokinetics: The plasma kinetics of amino acids and their integration in metabolic pathways are well established. It should nevertheless be noted that, in uremic patients, the plasma disturbances do not seem to depend on digested amino acid intake, and that the post-absorptive kinetics seems to be disturbed very early in the development of the disease.
In normal individuals, there is an increase in the plasma level of keto-analogues, 10 min after oral ingestion. These levels reach values that are approximately 5 times higher than the initial level. Peak levels are reached within 20-60 min, and normal levels are reached again after 90 min. Gastrointestinal absorption is thus very rapid. In the plasma, a simultaneous increase in levels of the keto-analogue and the corresponding amino acid show that transamination of the keto-analogues is very rapid. Due to the natural pathways of disposal of α-ketonic acids in the organism, it is probable that exogenous intakes are very rapidly integrated into metabolic cycles. Ketoacids follow the same catabolic pathways as the classical amino acids. No specific study on ketoacid excretion has been performed to date.
Toxicology: Preclinical Safety Data: Preclinical data reveal no special hazard for humans based on conventional studies of acute and repeated dose toxicity, safety pharmacology and genotoxicity. Ketosteril was found to show no teratogenic property.
  Ketosteril MIMS Class Other Drugs Acting on the Genito-Urinary System
Ketosteril ATC Classification G04BX - Other urologicals ; Used in the treatment of urological problems.
Ketosteril Poison Classification NP
 Ketosteril Presentation/Packing Film-coated tab 100's.

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